Tuesday, December 2, 2014


Common name: Gefitinib; ZD-1839; Iressa; ZD 1839; ZD1839
Trademarks:  Iressa
Molecular Formula: C22H24ClFN4O3
CAS Registry Number: 184475-35-2; 184475-56-7 (diHCl); 184475-55-6 (mono HCl)
CAS Name: N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide
Molecular Weight: 446.9076
Activity:  Antineoplastic; Tyrosine Kinase Inhibitors; EGFR Inhibitors; Inhibitors of Signal Transduction Pathways; Protein Kinase Inhibitor; erbB1 Inhibitor; Head and Neck Cancer Therapy; Liver Cancer Therapy; Lung Cancer Therapy; Non-Small Cell Lung Cancer Therapy; Oncolytic Drugs

Gefitinib synthesis: WO1996033980A1

Gefitinib synthesis: WO2005070909A1

1. Gibson, K. H.; Quinazoline derivatives. WO1996033980A1
2. Jyothi, P. R.; et. al. An improved process for the preparation of gefitinib. WO2005070909A1
3. Rao, D. R.; et. al. Process for the preparation of gefitinib. EP2155656A2