Monday, March 2, 2015


Common name: Indiplon; NBI-34060
Trademarks:  Somposure
Molecular Formula: C20H16N4O2S
CAS Registry Number: 325715-02-4
CAS Name: N-methyl-N-[3-[3-(thiophene-2-carbonylpyrazolo[5,1-b]pyrimidin-7-yl]phenyl]acetamide
Molecular Weight: 376.099
Activity: GABA-A Receptor Agonists; Hypnotics and Sedatives;Ttreatment of Insomnia; Non-benzodiazepine Hypnotic
Status: Launched 2007/Discontinued/Investigational
Originator: Neurocrine Biosciences/Pfizer

Indiplon synthesis: Important intermediate US6399621B1

Indiplon synthesis: Drugs Fut 200328, 739-746
Indiplon synthesis: US6399621B1

1. Dusza, J. P.; et. al. N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1, 5-a]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto. US6399621B1
2. Sorbera, L. A.; et. al. Indiplon Drugs Fut 2003, 28, 739-746.
3. Neubauer, D. N. Indiplon: the development of a new hypnotic. Expert Opin Investig Drugs 2005, 14(10), 1269-1276. (activity)